Hepatocellular carcinoma
Conditions
Interventions
control group :Postoperative pain relief was achieved through the use of traditional intravenous pumps containing opioid drugs.
C-ESPB group:Postoperative use of ESPB combined with a non-opioid intravenous pump for analgesia
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Hepatocellular carcinoma patients scheduled for elective open major hepatectomy under general anesthesia (resection of >= 3 liver segments), aged 18–80 years, with American Society of Anesthesiologists (ASA) physical status classification I–III, and Eastern Cooperative Oncology Group (ECOG) performance status score of 0–1.
Exclusion criteria
Exclusion criteria: 1. Patients who clearly asked for laparoscopic surgery; 2. Patients with a body mass index >= 30 kg/m2 or 2 times the normal upper limit); 8. Patients with severe spinal deformities; 9. Patients with distant tumor metastases; 10. Patients who had undergone hepatectomy (segment 50 mmHg; 16. Patients with poorly controlled acute or active infections (infection-induced fever > 38?); 17. Patients with poorly controlled hypertension or diabetes; 18. Patients with severe mental diseases or disorders; 19. Patients with suspicious systemic or regional nervous system diseases; 20. Patients with receiving systematic administration of corticosteroids; 21. Patients requiring concomitant surgical treatment for other diseases; 22. Patients with chronic pain or opioid use histories; 23. Women who were pregnant or breastfeeding; 24. Patients with other underlying serious diseases; 25. Patients who were unable or refused to comply with the treatment and monitoring required by the study; 26. Patients participating in other clinical trials; 27. Patients who refused to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the cumulative pain time curve at rest and movement 48 hours after surgery (AUCPACU-48h); | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting;The time of the first defecation after the operation;Postoperative VAS score (PACU, 12 h, 24 h, 48 h, 72 h, 96 h);The frequency of postoperative remedial analgesic administration of NSAID and pethidine within the first 48 hours after the operation and after the first 48 hours after the operation;Postoperative hospital stay;The time of the first time out of bed after the operation; | — |
Countries
China
Contacts
Public ContactWang Danfeng
Fujian Provincial Hospital
Outcome results
None listed