Rosacea
Conditions
Interventions
Treatment group(T1):Minocycline 50mg bid+base bid+centella asiatica containing repair mask tiw
Control group(C1):Minocycline 50mg bid+base bid
Treatment group(T2):Centella asiatica containing repair mask+base, tiw
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University Medical School
Eligibility
Sex/Gender
Female
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet the clinical diagnosis criteria of rosacea; rosacea score IGA >=3 points; 2. Women, between 25-55 years old; 3. Subjects should fully understand the content of trial, be willing to participate in the trial, and have signed an informed consent form; 4. No previous cosmetic adverse reactions reported; 5. Subjects are accustomed or have a desire to use a mask; 6. Physical examination revealed no abnormality, no history of serious cardiac, hepatic, renal, digestive, neurologic, psychiatric and metabolic disease; 7. No drug was taken during 1 month before treatment; no antibiotics were used topically in the past 1 week.
Exclusion criteria
Exclusion criteria: 1. The subject dose not meet the physical examination in inclusion criteria; 2. Pregnant, lactating women; 3. Be allergic to the ingredients or excipients of the trial drug; 4. Participated in any other clinical investigation within three months before the beginning of this trial; 5. Frequent user of Chinese herbal medicines, sleeping pills, sedatives, tranquilizers, or other addictive drugs; 6. Alcoholics, mental patients; or the subject can not follow doctor's advice; 7. Suffering from cardiopulmonary insufficiency or severe underlying diseases; 8. Suffering from other skin conditions that may interfere with the clinical assessment of acneiform skin evaluation and/or pose a risk to the subject, or have other serious skin disease history; 9. The investigator thinks that there are other reasons to exclude the subject in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visia CR;TEWL;Corneometer;Rosacea IGA;Lesion index;SSRI;Redness score;Dryness score;Desquamation score;Acne-QOL;Sensitivity scale;Comfortableness; | — |
Secondary
| Measure | Time frame |
|---|---|
| skin temperature;Sebumeter;skin pH;a value;melanin;redness; | — |
Countries
China
Contacts
Public ContactJie Zheng
Ruijin Hospital, Shanghai Jiao Tong University Medical School
Outcome results
None listed