Hypothalamic pituitary disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. The standard deviation according to the height of the bones is below -2 SD; 2. Aged 3-18 years; 3. the adult life expectancy is short (the male lifetime is <160cm, the female lifetime is <150cm).
Exclusion criteria
Exclusion criteria: 1. Chronic liver and kidney dysfunction, congenital heart disease, pituitary tumors and other organic systemic diseases; 2. combined with skeletal dysplasia, chromosomal abnormalities and other genetic metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height;Insulin-like growth factor 1;Insulin-like growth factor binding protein 3;bone age;Growth hormone peak; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other relevant laboratory indicators; | — |
Countries
China
Contacts
Affiliated Hospital of Jining Medical University