Post infectious cough (wind-cold lung syndrome)
Conditions
Interventions
High dose group:Kemin capsule 5 pills/time, 3 times/day, oral.
Middle dose group :Kemin capsule 3 pills + simulant 2 pills/time, 3 times/day, oral.
Low dose group:Kemin capsule 1 pill + simulant 4 pills/time, 3 times/day, oral administration.
Sponsors
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for Post infectious cough; 2. It conforms to the standard of TCM diagnosis and syndrome differentiation of cough-wind-cold lung syndrome; 3. VAS score of cough >=60 (0-100mm scale); 4. Duration of cough is 3-6 weeks; 5. Aged 18 to 65 years; 6. The informed consent process conforms to the ethical requirements, and subjects or legal representatives sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Meet the screening criteria for common causes of chronic cough (CVA, UACS, EB, GERC). 2. Meet the screening criteria for pertussis. 3. History of cough-related chronic lung disease (including but not limited to bronchiectasis, chronic bronchitis, bronchial asthma, COPD, bronchial lung cancer, trachea-bronchial/tuberculosis). 4. Taking ACEI preparation. 5. Smoke, or quit for less than 6 months. 6. Combined with known immunocompromised or immunocompromised diseases. 7. It conforms to the standard of TCM diagnosis and syndrome differentiation of Yin deficiency/damp-heat constitution. 8. Body temperature (underarm) =37.3?. 9. Complicated with serious cardiovascular, respiratory, digestive, urinary, hematopoietic and metabolic diseases. 10. The upper limit of normal values of ALT and AST > is 1.5 times, and the upper limit of normal values of Cr >. 11. Suspect or have a history of alcohol or drug abuse. 12. Persons who are legally disabled (blind, deaf, mute, mentally retarded, mentally retarded, etc.). 13. Known or suspected allergies to the tested drug ingredients. 14.Women who are pregnant or preparing to become pregnant or lactating. 15. Participated in clinical trials of other drugs within the past 3 months. 16. The investigator considers it inappropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough disappearance time;Incidence of clinical adverse events/reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cough disappearance rate;Cough VAS score AUC;Changes in cough questionnaire (LCQ) scores;Cough symptom (daytime, night) integral change;Curative effect of TCM syndrome;Vital signs;Blood routine, urine routine, electrocardiogram, liver and kidney function, urine enzyme; | — |
Countries
China
Contacts
Public ContactLiu Min
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed