Robot-assisted endoscopic surgery
Conditions
Interventions
Group 1:maintain deep neuromuscular blockade during surgery
Group 2:maintain moderate neuromuscular blockade during surgery
Sponsors
the Department of Anesthesiology, General Hospital of Southern Theater of the Chinese PLA
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: patients of ASA I - III, aged >=65 years, who will be scheduled for elective Robotic-assisted endoscopic surgery in ST position.
Exclusion criteria
Exclusion criteria: Hypersensitivity to study medicine; serious systemic disease; obstructive sleep apnea-hypopnea syndrome; suspected difficult tracheal intubation; body mass more than 28kg/m2; history of drug or alcohol abuse; MMSE scale before the operation less than 27; refuse to participate the study; refuse to write informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pneumoperitoneum pressure;IL-1 beta;IL-6;TNF-alpha;S-100 beta;NSE;the incidence of POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time from the administration of the reversal to the mean TOF ratio more than 0.9;The mean TOF ratio less than 0.9 at 10 and 15 minutes after administration of the reversal; | — |
Countries
China
Contacts
Public ContactXu Bo
General Hospital of Southern theater
Outcome results
None listed