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Study for the mechanism of probiotics improving patients' gastrointestinal symptoms by changing the composition of gut flora

Study for the mechanism of probiotics improving patients' gastrointestinal symptoms by changing the composition of gut flora

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026472
Enrollment
Unknown
Registered
2019-10-11
Start date
2020-10-15
Completion date
Unknown
Last updated
2019-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal symptoms

Interventions

Control group:Blank

Sponsors

Beijing Anzhen Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 25 to 70 years old adult patients who underwent colonoscopy due to the reason of gastrointestinal symptoms; 2. Patients volunteered to participate in this study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with mental and/or psychologic illness; 2. Patients who could not tolerate the examination of enteroscopy; 3. Patients with intestinal malignant tumors, polyps (diameter > 5mm), proctitis, inflammatory bowel disease and colorectal ulcer as a result of enteroscopy; 4. Patients who received drugs that affected the study within 1 month before and after the enteroscopy, including Antibiotics, other types of probiotics, A variety of drugs that inhibit the secretion of gastric acid, Cytokines, immunosuppressants and cytotoxicity, The Hormones; Other drugs that affect intestinal flora, patients with AIDS or have used immunosuppressive agents in the past one month; Patients who are participating in other clinical trials; 5. Patients who are allergic to polyethylene glycol electrolyte powder and/or Mei-Chang-An. Previous healthy, no basic gastrointestinal tract, liver, gallbladder and pancreatic diseases; no history of cardiovascular, respiratory, endocrinal, renal disease, hematological diseases and other systemic diseases; 6. With history of infectious diseases within the past 1 month.

Design outcomes

Primary

MeasureTime frame
Gastrointestinal Symptom Rating Scale;Small intestinal bacteria overgrowth;Serum level of inflammatory factor;Gut flora;

Countries

China

Contacts

Public ContactJIE ZHANG

Beijing Anzhen Hospital, Capital Medical University

zhangjie4155@sina.com+86 13601337670

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 17, 2026