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Effects of perioperative individualized PEEP on postoperative atelectasis and inflammatory response in obese patients

Effects of perioperative individualized PEEP on postoperative atelectasis and inflammatory response in obese patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026466
Enrollment
Unknown
Registered
2019-10-11
Start date
2019-11-01
Completion date
Unknown
Last updated
2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pulmonary complications

Interventions

Experimental group:Lung recruitment maneuver
Control group:PEEP of 5 cmH2O

Sponsors

Beijing Friendship Hospital Affiliated to Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. BMI >=32.5; 2. patients undergoing elective gastric volume reduction surgery under general anesthesia and laparoscopy; 3. Aged 18 to 60 years; 4. Moderate or high risk of postoperative pulmonary complications; 5. ASA grade I-III; 6. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. have severe chronic obstructive pulmonary disease (COPD, GOLD grade III-IV); 2. History of severe or uncontrolled bronchial asthma; 3. Patients with pulmonary metastases; 4. Renal replacement therapy is being performed before surgery; 5. Congestive heart failure (NYHA class III-IV); 6. Patients who cannot be extubated in time after surgery and need to be taken back to the ICU.

Design outcomes

Primary

MeasureTime frame
PaO2/FiO2;Proportion of collapsed lung area;Detection of inflammatory factors;post-cardiotomycardiogenic shock;

Secondary

MeasureTime frame
Blood gas analysis parameters;respiratory parameters;Anesthesia-related parameters;Postoperative follow-up related respiratory function and health economic index;

Countries

China

Contacts

Public ContactLinxin An

Beijing Friendship Hospital Affiliated to Capital Medical University

anlixin8120@163.com+86 13810248120

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 18, 2026