Gastric Cancer
Conditions
Interventions
3:Surgery+HIPEC(120mg/m2)
4:Surgery+HIPEC(150mg/m2)
5:Surgery+HIPEC(200mg/m2)
1:Surgery Only
2:Surgery+HIPEC(80mg/m2)
6:Surgery+HIPEC (200mg/m2)
Sponsors
Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. ECOG score 1.5 x 10^2/L); Platelet (>100 x 10^9/L); Serum total bilirubin was less than 1.5 times of the upper limit of normal value (ULN), alanine aminotransferase and aspartate aminotransferase were less than 2.5 times of ULN, and creatinine clearance rate was more than 50 ml/min. 7. Negative urinary or serum pregnancy test in women of childbearing age; 8. Projected survival of more than 3 months; 9. I would like to provide blood samples for pharmacokinetic study; 10. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Distant metastasis (e.g. liver metastasis, lung metastasis, para-aortic lymph node metastasis, etc.); 2) Peritoneal metastasis, ovarian metastasis or malignant ascites visible to the naked eye; 3) Recurrence of gastric cancer; 4) Primary gastric cancer has been resected; 5) Pregnant or lactating women; reproductive age patients (including men) who refuse to take contraceptive measures; 6) Serious uncontrolled recurrent infections, or HIV infections; 7) replicators of hepatitis B or C virus; 8) Clinically severe (i.e. active) heart disease with myocardial infarction or unstable angina pectoris within 6 months; 9) Uncontrolled diabetes; 10) Medical status (including follow-up and compliance) that may or must interfere with the research process; 11) Allergy to Chemotherapeutic Drugs or Related Drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Paclitaxel Contration;Complication rate; | — |
Countries
China
Contacts
Public ContactZhenggang Zhu
Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed