essential hypertension with anxiety
Conditions
Interventions
interventional group:tandospirone + amlodipine
Sponsors
National Center for Cardiovascular Disease
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-75 years; 2. systolic blood pressure >=140mmHg and/or diastolic blood pressure >=90mmHg; SBP=14 points on the Hamilton Anxiety Rating Scale (HAMA) and <29; 4. good compliance and given written informed consent.
Exclusion criteria
Exclusion criteria: 1. secondary hypertension; 2. secondary anxiety(post-stroke anxiety,postoperative anxiety,anxiety secondary to hyperthyroidism,and other anxiety caused by organic diseases,etc); 3. taken tandospirone or other anti-anxiety drugs in the past three months; 4. taking drugs with side effect on blood pressure(such as stimulants and oral contraceptives); 5. severe organic diseases or other life-threatening conditions; 6. allergic to tandospirone; 7. a total score >35 points on the Hamilton Depression Rating Scale (HAMD), or having inclination to suicide; 8. other conditions unsuitable for inclusion judged by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| control rate of hypertension (<140/90 mmHg) at the end of study (week 8); | — |
Secondary
| Measure | Time frame |
|---|---|
| the change of SeDBP/SeSBP compared to baseline;control rate of hypertension (<140/90 mmHg);the change of HAMA compared to baseline;response of SeDBP/SeSBP compared to baseline;heart rate;blood biochemical indicators;adverse events;Autonomic Physical Dyseregulation;Autonomic Balance;Accumulative Mental Stress; | — |
Countries
China
Contacts
Public ContactZengwu Wang, Zuo Chen
National Center for Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences
Outcome results
None listed