asthma
Conditions
Interventions
Case series:none
Sponsors
Department of respiratory and critical care medicine, Fuling Central Hospital, Chongqing
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Meet the standard of the 2016 edition of "guidelines for the prevention and treatment of bronchial asthma": (1) Recurrent attacks of wheezing, shortness of breath, with or without chest tightness or cough, night and morning Hair, often with exposure to allergens, cold air, physical, chemical stimulation and upper breath Aspiration infection, sports, etc. (2) During the attack, scattered or diffuse asthma can be heard in both lungs, and the expiratory phase is prolonged; (3) The above symptoms and signs can be relieved by treatment or by themselves; (4) Positive bronchial relaxation test; (5) positive bronchial stimulation test; (6) Mean daily diurnal variation rate of peak expiratory flow (continuous 7d, daily PEF diurnal), Sum of variation rate /7) > 10%, or PEF weekly variation rate {(highest PEF within 2 weeks Value - lowest PEF value) /[(highest PEF value within 2 weeks + lowest PEF value) x0.5] X} 100% > 20%; Meets all criteria (1) to (3) and any criteria (4) to (6), and divides Asthma can be diagnosed as wheezing, shortness of breath, chest tightness and cough caused by other diseases. 2. diagnostic criteria for atypical asthma: (1) Cough variant asthma: cough as the only or main symptom, without wheezing or shortness of breath The symptoms and signs of typical asthma, with variable airflow limitation objective examination Any one of them, except coughs caused by other diseases; (2) Chest tightness variant asthma: chest tightness as the only or main symptom, without wheezing or shortness of breath; The symptoms and signs of typical asthma, with variable airflow limitation objective examination Any one of them, except chest tightness caused by other diseases; (3) Insidious asthma: no recurrent attacks of wheezing, shortness of breath, chest tightness or cough, but long-term increased airway reactivity; 3. aged 18-70 years; 4. good cognitive function; 5. willing to participate in the clinical study of this project, and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) patients with FEV1 decreased by more than 20% induced by saline; (2) patients with severe cardiovascular and cerebrovascular diseases: patients with grade 3-4 cardiac function, severe hypertension (blood pressure after antihypertensive treatment was still higher than 160/100mmhg before examination), severe arrhythmia, aortic aneurysm, epilepsy, and increased intracranial pressure; (3) patients with pregnancy; (4) poor cognitive function of patients; (5) patients refused to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PRI;feno;Induction of sputum eosinophilic cell count;Peripheral blood eosinophil count;IgE; | — |
Countries
China
Contacts
Public ContactLiao Xiuqing
Fuling Central Hospital, Chongqing
Outcome results
None listed