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The clinical research for estrogen and progesterone vaginally sequential administration improving the endometrial receptivity in patients

The comparison of efficacy on endometrial receptivity between orally and vaginally administered sequential 17ß-estrogen and dydrogestrone in patients with premature ovarian failure

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026410
Enrollment
Unknown
Registered
2019-10-08
Start date
2019-10-15
Completion date
Unknown
Last updated
2020-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Repeated implantation failure

Interventions

A:Femostone, 2mg, oral administration
B:Femostone, 1mg, vaginal administration

Sponsors

The Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Twenty married women aged 22-33 years who were waiting for oocyte donation, had natural menopause more than 3 periods. The thickness of endometrium double wall was less than 5mm though transvaginal ultrasound imaging. Meanwhile the E2 level in serum was less than 10pg/ml.

Exclusion criteria

Exclusion criteria: Subjects were excluded if they had used hormonal therapy within the preceding 6 months and thrombus family history.

Design outcomes

Primary

MeasureTime frame
estradiol (E2);endometrial thickness;pinopodes;The immunohistochemical analysis of expression of ER, PR, MMP9, HOXA10, Integrinß3, LIF, vascular endothelial growth factor (VEGF);

Countries

China

Contacts

Public ContactXiaohui Deng

The Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University,

dxh0122@163.com+86 18560082026

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026