Postnatal depression
Conditions
Interventions
Experimental group:Butorphinol 0.15 mg/kg + Dexmedetomidine 2ug/kg
Control group:Butorphinol 0.15 mg/kg
Sponsors
Anesthesiology Department, Women's Hospital School of Medicine Zhejing University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Full-term (36-42 weeks), single fetus, planned cesarean section; (2) ASA II; (3) Aged 18 to 40 years; (4) Height > 150 cm, Weight < 80kg; (5) Can communicate freely; (6) Voluntarily signing the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with known hypersensitivity to butorphanol, dexmedetomidine hydrochloride, morphine or other drugs used in this study; 2. Long-term use of narcotic analgesics, sedatives or non-steroidal anti-inflammatory drugs; 3. Opioid dependence or tolerance; 4. Low placental function or gestational hypertension; 5. radycardia, heart rate < 60 beats/min; 6. Pacental dysfunction or gestational hypertension 7. Previous mental illness or depression; 8. Combined with craniocerebral injury and intracranial hypertension; 9. Serious abnormal heart, lung, liver and kidney function; 10. In the past three months, had participated in clinical research of other drugs; 11. The researchers considered it inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edinburgh depression scale;Postoperative pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart;Blood Pressure; | — |
Countries
China
Contacts
Public ContactXinzhong Chen
Women's Hospital School of Medicine Zhejing University
Outcome results
None listed