Patients undergoing bronchoscopy
Conditions
Interventions
Atomization group :Inhalation of dexmedetomidine 1 ug/kg before operation
Venous group:Preoperative intravenous infusion of dexmedetomidine 0.5ug/kg
Sponsors
The Second Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. First bronchoscopic examination; 2. ASA I-II grade; 3. Aged 18 to 65 years, regardless of gender.
Exclusion criteria
Exclusion criteria: None of the following can be included in this study: 1. The contraindication of bronchoscopy; 2. Allergic history of lidocaine or previous local anesthetics; 3. Those who are taboo or intolerant of nebulization inhalation therapy; 4. Severe airway stenosis and acute infection; 5. Arrhythmia: (1) Sinus arrhythmia with ventricular rate less than 45 beats/min, atropine test negative; (2) Atrioventricular block or intraventricular block of degree II or above; Other high-risk arrhythmias with sinus arrest, such as sick sinus syndrome (SSS). 6. Severe cardiac insufficiency: New York Heart Association Heart Function Classification (NYHA Classification) III or above; 7. Liver insufficiency: abnormal biochemical indicators of liver function (the range of indicators and normal values is 7.1); 8. Women awaiting delivery or during childbirth or breastfeeding; 9. Those who have difficulty in evaluating their preoperative state of consciousness independently and accurately completing the relevant questionnaires; 10. Those who used amphotericin B lipid complex, amphotericin B conventional colloid, ganofloxacin, diazepam, phenytoin sodium, oxamicin, pantoprazole, irinotecan and other contraindicated drugs compatible with dexmedetomidine. 11. Have a history of psychotropic drugs; 12. Smoking and taking drugs or bananas which affect the level of norepinephrine within 48 hours before operation; And/or patients who meet the criteria that any other researcher considers unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-rating score of comfort of patients undergoing bronchoscopy after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of norepinephrine (NE) levels;Visual Satisfaction Scale (VAS) of Surgeons;24-hour post-operative anxiety score;Effectiveness of heart rate systolic pressure product (RPP) control; | — |
Countries
China
Contacts
Public ContactZhang Pengbo
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed