Nephrotoxicity of cisplatin
Conditions
Interventions
A:LIPC+Sham LIPC
B:Sham LIPC+LIPC
Sponsors
Changzhou second people's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Pathohistology or cytology confirmed that chemotherapy was needed in the treatment; 2. Karnofsky(kps) >=70; 3. All the options were combined chemotherapy with cisplatin, and cisplatin was given intravenously, 75mg/m2 intravenous drip.
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years old; 2. Allergic to cisplatin and with contraindication of chemotherapy; 3. patients with serious heart, liver, or other kidney diseases, and patients with peripheral vascular diseases affecting the upper limbs; (4) those who used contrast agent or other nephrotoxic drugs within 30 days or those who drank alcohol within 7 days; (5) those who used inhibitors of transporters secreted by cisplatin into the urine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of AKI with cisplatin; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;blood urea nitrogen;albumin;white blood cells;24-hour urinary neutrophil gelatinase-associated apolipoprotein(NGAL);24-hour urinary kidney injury factor-1 (KIM-1);eGFR (calculated by MDRD); | — |
Countries
China
Contacts
Public ContactTongqiang Liu
Changzhou No 2. People's Hospital
Outcome results
None listed