Alzheimer's disease
Conditions
Interventions
Patch:Rivastigmine transdermal patch
Oral:Oral anti-dementia drugs
Sponsors
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 50 years, male or female; 2. Meet the NINCDS-ADRDA criteria for probable AD 3. MMSE score is 10-26 points (including 10 and 26 points); 4. Hachiski ischemia index score(HIS) <= 4; 5. Hamilton depression scale (HAMD) score <= 7; 6. Plain scan of brain MRI(include at least the T1, T2, FLAIR sequence) and/or Longitudinal oblique coronal position of vertical hippocampu is essential: for objects <= 70 years old Fazeca scale for WM lesions should be less than grade 1; for subjects over 70 years old Fazeca scale for WM lesions should be less than grade 2; There were less than or equal to 2 lacunar cerebral infarction larger than 2cm in diameter, and thereare no infarction in key parts such as thalamus, hippocampus, entorhinal cortex, paracorhinal cortex, cortex and other subcortical gray matter nuclei. MRI shows that AD is the most likely. 7. Good audiovisual, free movement, and able to cooperate with examination and treatment; 8. Have at least one reliable caregiver who has at least 2 hours of daily contact with the patient; 9. Informed consent should be signed.
Exclusion criteria
Exclusion criteria: 1. Dementia caused by other reasons: vascular dementia, and central nervous system infection, Creutzfeldt-Jakob disease, Parkinson's disease, Huntington's disease, DLB, other physical and chemical factors (such as, alcoholism, drug poisoning of carbon monoxide poisoning, etc.), body disease (such as hepatic encephalopathy, pulmonary encephalopathy), Diseases of the endocrine system (such as thyroid disease, parathyroid disease) and dementia caused by vitamins or other causes; 2. Participated in all kinds of types of clinical trials/studies within 3 months before the study begin; 3. Patients with contraindications to research drugs; 4. Patients with contraindications to MRI; 5. Currently, anticholinergic drugs (such as atropine, anisodamine, scopolamine, scopolamine butylbromide, belladonna, prubenectin, etc.) and/or cholinergic agents (such as acetylcholine, tranexamethyl choline, formylcholine, furrotin, etc.) are used; 6. Patients considered unsuitable for inclusion by the researchers, in addition to other reasons mentioned above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ZBI score; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE score;ADL score;NPI score;CIBIC-plus score;Morisky score; | — |
Countries
China
Contacts
Public ContactLiu Jun
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Outcome results
None listed