Relationship between preoperative peripheral blood angiotensin II and its receptor levels and postoperative chronic pain

Relationship between preoperative peripheral blood angiotensin II and its receptor levels and postoperative chronic pain in patients undergoing total knee arthroplasty

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900026277

Enrollment

Unknown

Registered

2019-09-28

Start date

2019-10-01

Completion date

Unknown

Last updated

2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orthopedic surgery

Interventions

AngII 92.3-421.1pg/ml group + AngII >421.1pg/ml group:N/A

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: From October 2019 to February 2020, patients with osteoarthritis underwent the first unilateral total knee arthroplasty in orthopaedics department of our hospital. ASA I-III, aged 30-70, BMI 18-24 kg/m2.

Exclusion criteria

Exclusion criteria: Patients with severe liver and renal dysfunction and abnormal coagulation function; patients with severe cardiovascular disease; patients with severe pulmonary dysfunction; patients taking angiotensin converting enzyme inhibitor (ACEI) and angiotensin II receptor antagonist (ARB) antihypertensive drugs.

Design outcomes

Primary

Measure	Time frame
angiotensin;angiotensin receptor;Pain assessment parameter;Pittsburgh sleep quality index;	—

Contacts

Public ContactWang Di

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China

13515604253@163.com+86 0551-62283963

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026