Study for the effect of heparin in the treatment of Pyrrolidine alkaloids-induced hepatic sinusoidal obstruction syndrome

Study for the therapeutic effect of heparin in the treatment of Pyrrolidine alkaloids-induced hepatic sinusoidal obstruction syndrome

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900026242

Enrollment

Unknown

Registered

2019-09-28

Start date

2019-10-01

Completion date

Unknown

Last updated

2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatic sinusoidal obstruction syndrome

Interventions

Experimental group:subcutaneous injection of low molecular weight heparin

Control group:Symptomatic supportive treatment of traditional hepatoprotective and diuretic therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged >=18 years; 2. Hepatic sinusoidal obstruction syndrome induced by Pyrrolidine alkaloids; 3. Medium or large amount of ascites; 4. T-Bil>34.2umol/L.

Exclusion criteria

Exclusion criteria: 1. Patients with active bleeding or coagulation system-related disease (such as haemophilia,aplastic anemia, etc); 2. Patients with a bleeding tendency: uncontrollable severe hypertension, intracranial hypertension, retinal vascular diseases, peptic ulcer in the active period,etc; 3. Prolonged prothrombin time ( PT) >10 s; 4. Allergy to low molecular weight heparin and its derivatives; 5. Previous medical history of thrombocytopenia associated with the use of low molecular weight heparin; 6. Severe renal dysfunction; 7. Children or pregnant woman; 8. Having a history of surgical operation in short term.

Design outcomes

Primary

Measure	Time frame
Liver function;Blood coagulation function;	—

Secondary

Measure	Time frame
Computed Tomography;Magnetic Resonance Imaging;	—

Countries

China

Contacts

Public ContactYuhu Song

yuhusong@163.com+86 15007187581

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026