Non-small Cell Lung Cancer with brain metastases
Conditions
Interventions
Case series:hypofractioned stereotactic radiotherapy
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed NSCLC; brain parenchymal metastases confirmed by enhanced MRI; have no or mild neurological symptoms which can be controlled by corticosteroid and dehydration treatment; 2. EGFR or ALK mutation is positive; 3. EGFR-TKIs or ALK-TKIs were effective for extracranial lesions; 4. ECOG PS 0-2; 5. Aged 18-75 years; 6. Never received brain radiotherapy previously; 7. At least one measurable intracranial lesion according to RECIST criteria; 8. Normal organ function; 9. Serum test of pregnancy should be negative for childbearing age women within 7 days before treatment; all enrolled patients (male or female) should have adequate contraception throughout and within 4 weeks after the treatment; 10. The patient must fully understand and voluntarily sign the informed consent form prior to treatment.
Exclusion criteria
Exclusion criteria: 1. Spinal cord or meninges metastases have been confirmed by MRI or CSF. 2. Patients who had registered in or dropped out of study previously. 3. Pregnant or lactating women. 4. The researcher believes that the subject may not be able to complete the study or comply with the requirements of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intracranial PFS;intracranial ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;overall survival; | — |
Countries
China
Contacts
Public ContactZhou Lin
West China Hospital, Sichuan University
Outcome results
None listed