Esophageal Carcinoma
Conditions
Interventions
experimental group:Surgery+Postoperative prophylactic chemoradiotherapy
Sponsors
Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Postoperative pathology confirmed esophageal squamous cell carcinoma. 2. The postoperative pathological stage was pT1-2, N+, M0 or pT3-4, N0-3, M0. 3. There were no residual metastasis lymph node lesions in supraclavicular and abdominal cavity before entering the group. 4. There is a perfect staging examination before operation. 5. No matter what kind of operation, the number of lymph nodes should be more than 15, and there should be complete data of postoperative pathological stage. 6. Complete medical history and physical examination within six weeks of admission to this study. 7. Chest enhanced ct was performed within six weeks of entry into this study (pet/ct as an option). 8. EKG was performed in the first six weeks of random grouping in this study. 9. The ECOG score is 0-1. 10. Randomized distance operation time is less than 8 weeks. 11. More than 18 years old, less than 70 years old. 12. (1) Blood routine examination: absolute neutrophil count (ANC) >=1.5 x 10^9/L, platelets >=100 x 10^9/L hemoglobin >= 9 g/dL; (2) Liver function: total bilirubin = 40 mL/min; 13. Both fertile women and men who take part in clinical trials need to take birth control. 14. Written informed consent form being signed. Agree to follow the study protocol and follow up procedures.
Exclusion criteria
Exclusion criteria: 1. Previous history of malignant tumors (except skin cancer, or in situ breast cancer, oral cancer, cervical cancer, etc., with an expected survival time of more than 2 years). 2. Multiple primary carcinoma of esophagus. 3. There are the following inclusion diseases: 1) Uncontrolled angina pectoris and heart failure, with a history of hospitalization in recent 3 months; 2) There was a history of myocardial infarction in recent 6 months; 3)In the presence of acute bacterial or fungal infections requiring antibiotic treatment; 4)If there is a chronic obstructive pulmonary disease attack or other pulmonary disease that needs to be hospitalized; 5) There are drug abuse and other adverse drug addiction and aids disease or virus carriers; 6) Have uncontrollable seizures or lose insight as a result of mental illness. 4. Women or men with fertility who do not intend to receive contraceptive treatment and treatment. 5. Local recurrence or distant metastasis was found before grouping.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease-Free Survival Time (DFS);Overall Survival Time (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of treatment; | — |
Countries
China
Contacts
Public ContactJin Gao
Anhui Provincial Cancer Hospital
Outcome results
None listed