postoperative sleep disorder
Conditions
Interventions
placebo group:placebo
5 mg melatonin group:5 mg melatonin
10 mg melatonin group:10 mg melatonin
Sponsors
Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) ASA class I~ II; (2) aged from 18 to 65 years; (3) scheduled for laparoscopic total hysterectomy under general anesthesia; (4) able to understand the scale content and willing to sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) preoperative score of PSQI > 7; (2) previous central nervous system disease or mental disease; (3) suffering from other endocrine and metabolic diseases (thyroid dysfunction, adrenocortical dysfunction, etc.); (4) a history of serious and chronic diseases of heart, liver and kidney; (5) taking sedatives and antidepressants; (6) those who are dependent on drugs or alcohol; (7) severe hearing or visual impairment, unable to communicate effectively with doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index;St.Mary's Hospital Sleep Questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary melatonin;Salivary cortisol;Plasma interleukin-6, interleukin-10, tumor necrosis factor concentration;Numerical rating scale; | — |
Countries
China
Contacts
Public ContactZhang Yueying
Xuzhou Medical Univetsity
Outcome results
None listed