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Effect of metformin on breast density in premenopausal overweight /obese women

Effect of metformin on breast density in premenopausal overweight /obese women

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026211
Enrollment
Unknown
Registered
2019-09-26
Start date
2020-06-01
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

C:C
M:M

Sponsors

Chongqing University Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 54 Years

Inclusion criteria

Inclusion criteria: The subjects of this study were non-menopausal overweight/obese women in Chongqing Tumor Hospital from June 1, 2020 to December 31, 2021. The recruitment conditions for this study were as follows: 1. Female, 21-54 years old; 2. Body mass index (>= 25) or waist circumference (>= 80 cm); 3. Pre-menopausal 6 months before admission (clinical menstrual history inquiry and detection of FSH and E2); 4. 12 months before admission, no abnormal mammograms were found in women over 5 and 50 years old; 5. Understanding and willing to sign written informed consent.

Exclusion criteria

Exclusion criteria: 1. Postmenopausal women (including those with premenopausal amenorrhea for at least 12 months before admission, or with history of hysterectomy and bilateral salpingoovariectomy); 2. Severe liver and kidney dysfunction, severe malnutrition, albumin < 25g/L, severe cardiopulmonary disease, unstable condition; 3. Complicated with diabetes and hyperemia. Patients with hypertension, coronary heart disease, stroke, malignant tumors, etc. 4. Those with uncontrolled severe infection; 5. Pregnant and lactating women; 6. Those with mental and neurological diseases who are unable to cooperate or unwilling to cooperate.

Design outcomes

Primary

MeasureTime frame
Breast density;adiponectin;

Secondary

MeasureTime frame
HOMA-IR;

Countries

China

Contacts

Public ContactQinan Wu

Chongqing University Cancer Hospital

wqn11@126.com+86 13452867542

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026