depression
Conditions
Interventions
1:rTMS therapy (L-DLPFC)+ Escitalopram oxalate tablets (10mg/d)
2 :rTMS therapy (left V1 area) + Escitalopram oxalate tablets (10mg/d)
Sponsors
Zhongda Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet diagnostic criteria for depression; 2. Show a 24-item Hamilton Rating Scale for Depression (HRSD-24) score of at least 18; 3. Aged 18-55 years; 4. Willing to sign informed consent and be able to comply with the research plan; 5. Without obvious intelligent disorder and could understand the follow-up questionnaire survey.
Exclusion criteria
Exclusion criteria: 1. Individuals meet or met the following conditions: schizophrenia, delusional disorder, bipolar affective disorder, dementia, amnesiac, or other serious cognitive impairments, impaired mental developments, mental disorders caused by physical illness or substance abuse; 2. With the history of brain trauma or other known pathological changes of the central nervous system; 3. Psychotic symptoms or suicidal behavior during depressive episodes; 4. With endocrine and blood disease or significant abnormalities in heart, liver and kidney functions; 5. Have received the systematic treatment with elector-shock or rTMS; 6. Being treated with an antidepressant other than escitalopram and unwilling to receive a dressing change; 7. There are contraindications to rTMS or brain magnetic resonance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HRSD-24 score;adverse events scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery Depression Rating Scale;Beck Suicide Ideation Scale;Life Event Scale;mini-mental state examination;Montreal Cognitive Assessment;Emotional-Stroop task;electroencephalogram;visual evoked potential;Event-related potential P300; | — |
Countries
China
Contacts
Public ContactZhijun Zhang
Zhongda Hospital
Outcome results
None listed