breast cancer
Conditions
Interventions
Gold Standard:1. Pathological diagnosis as the gold standard for breast cancer diagnosis.
2. Chemotherapy response according to RECIST (version 1.1) solid tumor efficacy evaluation criteria.
RNR-Seq 
analysis 
and 
analysis.
Sponsors
Medical Research Ethics Committee of Binzhou Medical University Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women aged more than 18 years. 2. Histologically proven invasive carcinoma of the breast and locally advanced stage (tumor size >= 2 cm). 3. Neo-adjuvant chemotherapy with anthracyclines and taxanes. 4. Expected survival >= 6 months. 5. Initial required laboratory values: Absolute neutrophil count >/= 1.5 x 10^9/L Platelet count >= 100,000 x 10^9 /L Creatinine clearance >= 50mL/min (calculated by Cockcroft-Gault method) Liver function tests (AST, ALT, total bilirubin) <= 2.5 x ULN Urine or serum HCG negative (if female of childbearing potential). 6. No prior chemotherapy. 7. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of metastatic disease at diagnosis. 2. Breast Cancer inflammatory. 3. Rare histologic subtypes (non ductal lobular and not). 4. Other cancer (except basal cell skin carcinoma and cancer of the cervix in situ adequately treated and curative) treated in the previous 5 years. 5. Patient pregnant or nursing or of childbearing age without effective contraception. 6. Breast cancer in men. 7. Legal incapacity or limited legal capacity. medical or psychological conditions allowing the subject to complete the study or to sign the consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| exosomes;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactWang Xiaohong
Binzhou Medical University Hospital
Outcome results
None listed