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The effects of one-lung ventilation mode on endogenous melatonin production and NLRP3 inflammasome activation in patients undergoing laparoscopic esophagectomy: a prospective randomized double-blind controlled study

The effects of one-lung ventilation mode on endogenous melatonin production and NLRP3 inflammasome activation in patients undergoing laparoscopic esophagectomy: a prospective randomized double-blind controlled study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026190
Enrollment
Unknown
Registered
2019-09-25
Start date
2019-09-24
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung protection

Interventions

Group A:ventilation mode
Group B:lung protective ventilation mode

Sponsors

The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 80 Years

Inclusion criteria

Inclusion criteria: ASA physical status I or II, need OLV during operation, aged 49-77 years.

Exclusion criteria

Exclusion criteria: Preexisting hypoxemia, diagnosed major obstructive or restrictive pulmonary disease (preoperative forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) <70% of predicted value), pulmonary infection before surgery, body mass index (BMI) of less than 20 or more than 35, need immune modulators.

Design outcomes

Primary

MeasureTime frame
IL-18;Melatonin;IL-1ß;—

Countries

China

Contacts

Public ContactWang Lixia

The First Affiliated Hospital of Anhui Medical University

wanglx87@163.com+86 18156051458

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 12, 2026