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Effect of rebamipide on duodenal mucosal barrier and inflammation of acute pancreatitis patients: a randomized controlled trial

Effect of rebamipide on duodenal mucosal barrier and inflammation of acute pancreatitis patients: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026180
Enrollment
Unknown
Registered
2019-09-25
Start date
2019-09-26
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute pancreatitis

Interventions

control group:Placebo

Sponsors

West China Hospitial, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) diagnosed with AP; (2) having AP for less than 5 days; (3) aged 18-70 years; (4) with the informed consent of the patient or his legal representative, voluntary subjects and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. patients with other serious organ diseases; 2. patients who had used other mucosal protective agents in the previous week or had used other mucosal protective agents for more than 3 days in two weeks; 3. patients who had a definite diagnosis of peptic ulcer within three months; 4. patients who had used NASIDs in the previous month; 5. patients who had previous gastroduodenal surgeries; 6. Patients with gastric or duodenal tumors; 7. patients with history of chronic pancreatitis or pancreatic cancer; 8. patients with anaphylaxis and heterogenous reaction to ribapamide; 9. patients who are unable to complete endoscopy due to serious illness or personal refusal; 10. pregnant or nursing women.

Design outcomes

Primary

MeasureTime frame
Histological inflammation score of duodenal mucosa;Endoscopic grading of duodenal inflammation;Implementation of enteral nutrition;

Countries

China

Contacts

Public ContactJing Li

West China Hospitial, Sichuan University

melody224@163.com+86 18980606763

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026