Chronic Hepatitis B
Conditions
Interventions
Sponsors
Shenzhen Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients meet the diagnostic criteria for chronic HBV carriers (1) serum HBsAg, HBeAg and HBV-DNA are positive; (2) patients are fluped 3 times in one year, whose serum ALT, AST are within the normal range; (3) Fibroscan10^5 IU/ml, <10^9 IU/ml; 6. Histological Knodell HAI<4 score, Ishak<=3 score, or Fibroscan<7.0 kPa; 7. Patient sign the informed consents and volunteer to participate in this clinical trial.
Exclusion criteria
Exclusion criteria: 1. Patients infect HIV, HCV and HDV; 2. Patients with metabolic or autoimmune liver disease; 3. Patients have a history of alcohol abuse or illicit drugs or participate in other clinical trials of hepatitis drugs within 30 days; 4. Serum ALT and AST levels show abnormality with one years; 5. Patients are treated with nucleoside or interferon for 24 weeks prior to enrollment; 6. Inactive HBsAg carriers; 7. Patients with cirrhosis or patients' AFP are increased; 8. Pregnant or lactating women; 9. Patients with mental disease and other serious organ diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum HBsAg;Serum HBeAg;Serum HBV-DNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| AFP;Fibroscan;Color Doppler ultrasound examination;Knodell HAI;Ishak; | — |
Countries
China
Contacts
Public ContactGuangdong Tong
Shenzhen Traditional Chinese Medicine Hospital
Outcome results
None listed