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Mechanism of abnormal NPPB gene expression inducing hypertension by causing ACE2-Ang(1-7)-Mas axis imbalance

The Roles of NPPB Gene Polymorphism in Hypertensive Patients and Its Transcription Level on RAS System

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900026148
Enrollment
Unknown
Registered
2019-09-23
Start date
2014-09-01
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension

Interventions

Hypertension group:NO
Non-hypertensive group:NO

Sponsors

The First Affiliated Hospital of Fujian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Hypertension group: 1. In the absence of antihypertensive drugs, systolic blood pressure (SBP)>=140mmHg and diastolic blood pressure (DBP)>=90mmHg were monitored for three times in the resting state, or the blood pressure level was lower than 140/90mmhg after the treatment of antihypertensive drugs; 2. Complete clinical history and related data; 3. Agree to participate in the project researcher. Non-hypertensive group: 1. systolic blood pressure < 140mmHg, diastolic blood pressure < 90mmHg; 2. Complete clinical history and related data; 3. Agree to participate in the project researcher.

Exclusion criteria

Exclusion criteria: Hypertension group: 1. secondary hypertension; 2. congestive heart failure, myocardial infarction, heart valve disease, coronary artery bypass surgery; 3. Cardiovascular and cerebrovascular diseases occurred within six months, such as myocardial infarction, arrhythmia, stroke; 4. Renal insufficiency; 5. Any condition that affects the 24-hour blood pressure dynamic (e.g. atrial fibrillation or arrhythmia); 6. Pregnancy; 7. Severe infection; 8. Malignant tumor. Non-hypertensive group: 1. Family history of hypertension; 2. body mass index(BMI)>40kg/m2; 3. congestive heart failure, myocardial infarction, heart valve disease, coronary artery bypass surgery; 4. Cardiovascular and cerebrovascular diseases occurred within six months, such as myocardial infarction, arrhythmia, stroke; 5. Malignant tumor; 6. Renal insufficiency; 7. Any condition that affects the 24-hour blood pressure dynamic (e.g. atrial fibrillation or arrhythmia); 8. Pregnancy; 9. Severe infection.

Design outcomes

Primary

MeasureTime frame
NPPB locus;NPPA locus;NT-pro-Brain Natriuretic Peptide;Angiotensin Converting Enzyme;Angiotensin Converting Enzyme 2;Angiotensinogen II;Angiotensinogen (1-7);Atrial natriuretic peptide;blood pressure;—

Secondary

MeasureTime frame
waistline;fasting blood-glucose;triglyceride;total cholesterol;low density lipoprotein;high density lipoprotein;height;weight;—

Countries

China

Contacts

Public ContactZeng Kai

The First Affiliated Hospital of Fujian Medical University

fymzk6822@163.com+86 13055291712

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026