sinonasal ACC
Conditions
Interventions
control group:endoscopic surgery and post-operative IMRT
experimental group:preoperative intra-arterial chemotherapy accompanying radiotherapy + surgery+post-operative IMRT
Sponsors
Eye & ENT Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. histologically proven ACC; 2. clinical stage T4aN0M0 or T4bN0M0; 3. aged between 20 and 75 years; 4. sufficient organ function as shown by a peripheral blood white blood cell count of at least 4000 cells per lL and 12,000 cells per lL or less; hemoglobin concentration of at least 9.5 g/dL; platelet count of at least 100 000 cells per lL; serum total bilirubin concentration of 2.0 mg/dL or less; aspartate aminotransferase of 100 IU/L or less; alanine aminotransferase of 100 IU/L or less; serum creatinine concentration of 1.2 mg/dL or less;
Exclusion criteria
Exclusion criteria: 1. regional or distant metastasis; 2. history of sinonasal malignancies; 3. pregnant or breathfeeding; 4. severe carotid stenosis as evaluated by ultrasonography; 5. intolerance to the surgery, radiotherapy or chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-year overall survival rate; | — |
Countries
China
Contacts
Public ContactLiu Quan
Eye, Ear, Nose and Throat Hospital, Fudan University
Outcome results
None listed