Prognosis of trimethylamine combined with short-chain fatty acids in patients with heart failure and intervention effects of microecological preparations

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900026103

Enrollment

Unknown

Registered

2019-09-21

Start date

2019-10-01

Completion date

Unknown

Last updated

2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

Experimental group:Microecological preparation+Conventional treatment

Control group:Conventional treatment

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The diagnostic criteria are in accordance with the Chinese Heart Failure Diagnosis and Treatment Guide 2018; 2. The heart color ultrasound measured LVEF <=40%, 3. NYHA classification II-IV; 4. Aged 18-75 years old.

Exclusion criteria

Exclusion criteria: 1. Those who are allergic to microecological preparations; 2. Severe liver dysfunction, alanine aminotransferase is 3 times higher than the upper limit of normal; 3. Severe renal insufficiency: endogenous creatinine clearance rate <=60 ml/min; 4. Patients with high blood system diseases or bleeding; 5. Combine serious infections; 6. Patients with malignant tumors; 7. Pregnant women.

Design outcomes

Primary

Measure	Time frame
Trimethylamine oxide;Short chain fatty acid;Major adverse cardiovascular events;all-cause death;Cardiac Function;	—

Secondary

Measure	Time frame
6 minute walk test;Minnesota Quality of Life Score;	—

Countries

China

Contacts

Public ContactLi Ruyi

Hebei General Hospital

gp1024@sina.com+86 13582816136

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026