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Effect of controlled hypertension before closing the incision on hemostasis in vertical partial laryngectomy

Effect of controlled hypertension before closing the incision on hemostasis in vertical partial laryngectomy

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026097
Enrollment
Unknown
Registered
2019-09-21
Start date
2019-09-24
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laryngeal cancer

Interventions

control group:In the controll group, the patients were injected the placebo of normal saline 0.1ml/kg 10 min before the closing the incision
controlled hypertension group:In the controlled hypertension group, the patients were intravenously injected of ephedrine (6mg) or norepinephrine (0.1mg) intermittenttly from 10 min before closing inc

Sponsors

Shanghai Eye, Ear, Nose, and Throat Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) The male patients who were scheduled to undergo vertical partial laryngectomy under general anesthesia; 2) ASA: I or II; 3) Aged 35 to 65 years; 4) BMI: 19 to 30.

Exclusion criteria

Exclusion criteria: 1) Abnormal coagulation function; 2) Had history of cardiopulmonary and cerebrovascular diseases; 3) Had history of head and neck chemo-radiotherapy and neck surgery; 4) Had a history of allergy to anesthetic drugs.

Design outcomes

Primary

MeasureTime frame
bleeding volume collections from the suction pipe above the balloon of the TOT plus negative pressure drainage;

Secondary

MeasureTime frame
incisional bleeding score;the frequency of bloody sputum aspiration;coughing score;nausea and vomiting score;

Countries

China

Contacts

Public ContactQing Fan

Shanghai Eye, Ear, Nose, and Throat Hospital, Fudan University

fanqing@eentanesthesia.com+86 18917785170

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026