hip and knee joint disease
Conditions
Interventions
Group B:1g of TXA was given at POD1 21:00 AM, POD2 09:00 AM and 21:00 PM respectively
Group C:POD1 and POD2 were given 10mg and 5mg dexamethasone at 09:00 AM respectively
Group D:POD1 10mg ofdexamethasone was given at 09:00 AM and 1g of TXA was given at 21:00 PM.POD2 5mg dexamethasone, then 1g TXA at 09:00 AM, and 1g TXA at 21:00 PM.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) patients with primary unilateral TKA due to terminal knee disease (osteoarthritis); (2) patients who voluntarily participate in clinical trials and sign informed consent; (3) no abnormalities were found in the preoperative color doppler ultrasound of both lower extremities; (4) patients who voluntarily participate in clinical trials and sign informed consent and have good compliance.
Exclusion criteria
Exclusion criteria: (1) patients with systemic infection including pulmonary infection and urinary tract infection not under control before surgery; (2) patients with abnormal preoperative inflammatory indicators (CRP > 20 mg/L); (3) patients with abnormal fibrinolysis index before operation (FDP > 5 mg/L); (4) stop taking anticoagulant or aspirin for less than 1 week; (5) clear TXA allergy or contraindication; (6) patients at high risk of thrombosis, including patients with atrial fibrillation, cardiac pacemaker and stent implantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRP;IL-6;TNF-a;Routine blood examination;DIC routine examination;Color doppler ultrasound of veins in both lower extremities;PLOS;Readmission rate;Reoperation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wound complications;Gastrointestinal hemorrhage; | — |
Countries
China
Contacts
Public ContactFuxing Pei
West China Hospital, Sichuan University
Outcome results
None listed