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Comparative Study on the Best Infusion Rate of Norepinephrine for Preventing Hypotension During Spinal Anesthesia for Single and Twin Cesarean Delivery

Comparative Study on the Best Infusion Rate of Norepinephrine for Preventing Hypotension During Spinal Anesthesia for Single and Twin Cesarean Delivery

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026068
Enrollment
Unknown
Registered
2019-09-20
Start date
2019-09-20
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

single and twin elective cesarean section

Interventions

Group A-1:Infusion of norepinephrine at a constant rate of 0.02ug/kg/min
Group A-2:Infusion of norepinephrine at a constant rate of 0.03ug/kg/min
Group A-3:Infusion of norepinephrine at a constant rate of 0.04ug/kg/min
Group A-4:Infusion of norepinephrine at a constant rate of 0.05ug/kg/min
Group A-5:Infusion of norepinephrine at a constant rate of 0.06ug/kg/min
Group B-1: Infusion of norepinephrine at a constant rate of 0.02ug/kg/min
Group B-2: Infusion of norepinephrine at a constant rate of 0.03ug/kg/min
Group B-3: Infusion of norepinephrine at a constant rate of 0.04ug/kg/min
Group B-4: Infusion of norepinephrine at a constant rate of 0.05ug/kg/min
Group B-5:Infusion of norepinephrine at a constant rate of 0.06ug/kg/min

Sponsors

Womens' Hospital, School of Medicine, Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria of group A were: (1) ASA grade 2; (2) parturients aged 18 to 40 years; (3) BMI= 37 weeks), elective Single-birth cesarean section. Inclusion criteria for group B were: (1) ASA grade 2; (2) puerpera aged 18 to 40 years; (3) BMI = 34 weeks) elective twin cesarean section.

Exclusion criteria

Exclusion criteria: Exclusion criteria for group A were: (1) contraindication of intraspinal anesthesia; (2) allergy to amide local anesthetics; (3) basal systolic blood pressure <= 100 mmHg; (4) pregnancy induced hypertension or preeclampsia; (5) gestational diabetes mellitus; (6) asthma and cardiac diseases requiring treatment; (7) refusal to sign informed consent; (8) its Other conditions: such as ruptured membranes, active labor process, twin and multiple pregnancy cesarean section, intrauterine growth restriction, placenta previa, fetal congenital abnormalities, etc. Exclusion criteria for group B were: (1) intraspinal anesthesia contraindication; (2) allergic to amide local anesthetics; (3) basal systolic blood pressure <= 100 mmHg; (4) severe gestational hypertension or preeclampsia; (5) uncontrolled severe gestational diabetes mellitus; (6) asthma and heart disease requiring treatment; (7) refusal to sign. Informed consent; (8) Other conditions: ruptured membranes, active labor, single, triplets and above cesarean section, intrauterine growth restriction, placenta previa, fetal congenital abnormalities, etc.

Design outcomes

Primary

MeasureTime frame
The incidence of hypotension;Number of interventions;Dosage of vasoactive drugs;Maternal outcomes (Nausea and Vomiting; Bradycardia; Tachycardia; Hypertension; Dizzy; Dyspnea);Maternal outcomes (Nausea and Vomiting; Bradycardia; Tachycardia; Hypertension; Dizzy; Dyspnea);

Countries

China

Contacts

Public ContactXiaowei Qian

Womens' Hospital, School of Medicine, Zhejiang University

qxwzhejiangedu@163.com+86 15700157161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026