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To investigate the effect of dexmedetomidine combined with thoracic paravertebral nerve block on stress response and perioperative safety patients undergoing thoracotomy: a randomized controlled trial

A randomized controlled clinical trial for dexmedetomidine combined with thoracic paravertebral nerve block on stress response and perioperative safety in patients undergoing thoracotomy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900026057
Enrollment
Unknown
Registered
2019-09-20
Start date
2019-09-23
Completion date
Unknown
Last updated
2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chest and lung disease

Interventions

General anesthesia group:General anesthesia
Thoracic paravertebral nerve block combined with general anesthesia:Thoracic paravertebral nerve block
Dexmedetomidine combined with thoracic paravertebral nerve block for general anesthesia:Dexmedetomidine combined with thoracic paravertebral nerve block

Sponsors

Yongchuan Hospital affiliated to Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: ASA graded as I-III; age range 18-75 years no gender; diagnosed as chest and lung disease, patients requiring thoracoscopic surgery.

Exclusion criteria

Exclusion criteria: 1. Preoperative blood pressure >= 180/110mmHg; 2. Liver and kidney function indicators below or above the normal range, eg: alanine aminotransferase (ALT): 5-40 U/ L, aspartate aminotransferase (AST): 8-40U / L endogenous Creatinine clearance rate: 80-120ml/min serum creatinine 44-133umol/L; 3. Arrhythmia, cardiac insufficiency (NYHAIII/IV); 4. Patients with abnormal coagulopathy; 5. History of mental illness; 6. Infection of the back puncture site; 7. Patients who died or gave up treatment during and after surgery.

Design outcomes

Primary

MeasureTime frame
Mean arterial pressure;Heart rate;Blood pressure;Sensory block recovery time;Pain visual analogue scale;Postoperative complications;Time to get out of bed after surgery;—

Secondary

MeasureTime frame
Analgesic drug dosage;hospitalized duration;—

Countries

China

Contacts

Public ContactPeng Mingqing

Yongchuan Hospital affiliated to Chongqing Medical University

pengmingqing2016@163.com+86 18623104219

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026