Effect of high pressure carbon dioxide pneumoperitoneum on postoperative immune function, inflammatory response and early cognitive function in elderly patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900026047

Enrollment

Unknown

Registered

2019-09-19

Start date

2019-09-27

Completion date

Unknown

Last updated

2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

1:low pneumoperitoneal pressure group and high pneumoperitoneal pressure (8~10mmHg)

2:high pneumoperitoneal pressure (13~15mmHg)

Eligibility

Sex/Gender

All

Age

60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients undergoing elective colon cancer radical surgery, aged 55-75 years, ASA grade I~II.

Exclusion criteria

Exclusion criteria: Refusal to study informed consent; presence of CNS-related or psychiatric disorders; regular administration of sedative or antidepressant; failure to communicate effectively due to language or hearing problems; MMSE scale score <20 points.

Design outcomes

Primary

Measure	Time frame
TNF-a;IL-1ß;IL-6;IL-4;IL-13;IL-10;ESR;PCT;CRP;natural killer cell;CD4+ cell/CD8+cell;Th17 cell;	—

Countries

China

Contacts

Public ContactBo Meng

Ningbo NO.2 Hospital

mengbo1206@163.com+86 18352990390

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026