poststroke cognitive impairment
Conditions
Interventions
Experimental group:remote limb ischemic conditioning
Control group:regular treatment
Sponsors
Zhabei District Central Hospital, Jing'an District, Shanghai , China
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. symptoms of focal neurological deficit and new cerebral infarct confirmed by the magnetic resonance diffusion-weighted imaging that met the diagnostic criteria for cerebral infarct as suggested by the Chinese Guideline for Diagnosis and Treatment of Ischemic Stroke (2014) (Chinese Stroke Society, 2014) (> 4.5 h after disease onset, beyond the indications of thrombolytic therapy); 2. aged 18 and 80 years; 3. stabilized vital signs and neurological symptoms for 24 h; and 4. Within 14 days after disease onset.
Exclusion criteria
Exclusion criteria: 1. patients with cognitive impairment prior to the stroke as indicated by the Informant Questionnaire on Cognitive Decline in the Elderly; 2. patients with disorders of consciousness; 3. patients with neurological diseases, such as brain trauma, epilepsy, encephalitis, and normal intracranial pressure hydrocephalus, which may cause cognitive disorders; 4. other brain diseases, such as brain tumors and multiple sclerosis, confirmed by the computerized tomography (CT)/magnetic resonance imaging (MRI); 5. patients with a Hamilton Depression Scale (HAMD) score >7 points or accompanied by other mental diseases; 6. apparent aphasia and/or dysarthria affecting the cognitive function assessment; 7. intracranial/external artery stenosis>50% (To analyze the degree of intracranial artery stenosis by TCDmeanow velocity >90 cm/s for the intracranial internal carotid artery, 100 cm/s for MCA, >80 cm/s for basilar artery or vertebral artery measured according to the Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis criteria (Zhao et al., 2011; Deweese et al., 1970); To analyze the degree of extracranial artery stenosis by carotid duplex ultrasound ); 8. systolic blood pressure >200 mm Hg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neuropsychological evaluation;P300 event-related potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum intercellular adhesion molecule-1;endothelin-1; | — |
Countries
China
Contacts
Public ContactWang Luojun
Department of Neurology, Zhabei District Central Hospital
Outcome results
None listed