Meibomian Gland Dysfunction
Conditions
Interventions
1:Er: YAG laser SMOOTH mode was used for tarsal conjunctiva conjunctival treatment
2:Eyelid skin was treated by Nd:YAG laser PIANO mode
Sponsors
Ophthalmology Center of the Second Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Volunteer to participate in this study, and sign the informed consent, willing to cooperate with treatment and follow-up; 1. Over 18 years old (including 18 years old), male or female; 2. Fitzpatrick skin types 1-4 3. SPEED rating >=6 points; 4. Meibomian gland function score =1 point.
Exclusion criteria
Exclusion criteria: 1. Fail to sign the informed consent; 2. Women during lactation or pregnancy; 3. Wear contact lens and acute eye inflammation or infection; 4. Eyelid margin has obvious scar or keratinization.Patients undergoing lacrimal duct embolization; 5. Received Eye surgery or Eyelid surgery or LASIK or Nerve palsy occurred in the treatment area Within 6 months prior to enrollment; 6. Presence of precancerous lesions, skin cancer or pigmentation in the treatment area.A history of migraine or epilepsy; 7. The treatment area has diseases that may be triggered by 560nm -- 2940nm light waves, such as herpes simplex type 1 and type 2, systemic lupus erythematosus and porphyria; 8. Have been tanned or shined in the last two weeks to a month, or exfoliated, hydroxy acid peels, etc. 9. One week after the injection of hyaluronic acid around the eyelid; 10. Taking photosensitive drugs, such as isotretinoin, tetracycline or st. John's wort; 11. Prescription of dry eye drops (other than artificial tears) within 48 hours before enrollment; 12. Had a history of radiotherapy for head and neck, and facial hyperintense pulsed light therapy within 1 year before enrollment;There was a history of chemotherapy in the first 8 weeks of the study, or radiotherapy or chemotherapy was expected within 8 weeks after intense pulsed light treatment; 13. Contraindications (mainly around the eyes) : onset of infection;Dysplastic mother spot;Tattoos.Severe concurrent skin conditions or any inflammatory skin conditions;Cold sores, open lacerations or abrasions;Chronic or epidermal viruses, fungi, or bacterial viruses;Exposure to sunlight or artificial sunlight in the 3 to 4 weeks prior to treatment;Patients with a history of skin cancer or a history of complications or precancerous lesions in the treatment area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tear break-up time;Meibomian Gland Score;standard dry eye questionnaire (SPEED) score;Fluorescence staining score of cornea; | — |
Countries
China
Contacts
Public ContactXiuming Jin
The Second Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed