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Effect of artificial liver support therapy initiation timing on clinical outcomes in patients with acute-on-chronic liver failure: a real-world multicenter prospective cohort study (INITIALS study)

Effect of artificial liver support therapy initiation timing on clinical outcomes in patients with acute-on-chronic liver failure: a real-world multicenter prospective cohort study (INITIALS study)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900025999
Enrollment
Unknown
Registered
2019-09-17
Start date
2020-08-01
Completion date
Unknown
Last updated
2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver failure

Interventions

Early initiation group :None
Delayed initiation group:None
Non-initiation group:None

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Aged 18-75 years, male or female. (2) Hepatitis B-related acute-on-chronic liver failure (Wu T, et al. Gut. 2018 Dec; 67(12): 2181-2191.). (3) The stage of disease development is at rising period. (4) The severity of the disease is staged in the early and middle stages.

Exclusion criteria

Exclusion criteria: (1) Patient has the following diseases: human immunodeficiency virus infection, obstructive jaundice, mental illness. (2) Patient has the following conditions: pregnancy, history of malignant tumors or suspected malignant tumors, plans to receive non-hepatic organ transplantation or any organ transplant.

Design outcomes

Secondary

MeasureTime frame
Occurrence rate of major complications of HBV-ACLF;Inflammatory factors;Biochemical indicator;Occurrence rate of complications during ALSS therapy;—

Primary

MeasureTime frame
Three-month survival;—

Countries

China

Contacts

Public ContactLang Bai

West China Hospital of Sichuan University

pangbailang@163.com+86 189 8060 2254

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026