Hypoxia respiratory failure after congenital heart disease surgery
Conditions
Interventions
Conventional group:Conventional PEEP and FiO2 protocol
Recruitment maneuver group:Recruitment maneuver
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: 1. Mechanical ventilation after cardiac surgery with complete anatomical correction and no intraventricular shunt; 2. Age: 28 days to 14 years; 3. Oxygen index PaO2/FiO2 < 300mmHg within 72 hours after surgery.
Exclusion criteria
Exclusion criteria: 1. Hemodynamic instability (defined as need for norepinephrine > 0.2 ug / kg/min or epinephrine > 0.2 ug / kg/min, or refractory metabolic acidosis); 2. Endotracheal tube without cuff; 3. Pneumothorax without a chest tube in place; 4. Bronchopleural fistula; 5. Increased intracranial pressure( > 20mmHg); 6. The clinician team deem the patient unacceptable candidate (such as pulmonary hypertensive crisis, poor right ventricular function); 7. Central nervous system complications have occurred; 8. Diaphragmatic paralysis; 9. Intracardiac shunt; 10. Failure to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of MV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygen index;Respiratory system dynamic compliance;Noninvasive mechanical ventilation duration;Days of stay in ICU;Hospitalization days;Postoperative pulmonary complications score;Reintubation rate in 48 hours after extubation;Ventilator-free days through day 28;Occurrence of serious adverse event; | — |
Countries
China
Contacts
Public ContactDeng Lijing
Intensive Care Unit, West China Hospital, Sichuan University
Outcome results
None listed