HFNC vs NPPV after early extubation for patients with AECOPD

High-flow nasal cannula versus noninvasive positive pressure ventilation therapy after early extubation for patients with acute exacerbation of chronic obstructive pulmonary disease: a multicenter randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900025974

Enrollment

Unknown

Registered

2019-09-16

Start date

2019-11-01

Completion date

Unknown

Last updated

2019-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obstructive pulmonary disease

Interventions

1:HFNC

2:NPPV

Eligibility

Sex/Gender

All

Age

40 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Aged 48 to 85 years with known chronic obstructive pulmonary disease (COPD). 2. Patients with hypercapnia respiratory failure treated with invasive mechanical ventilation due to bronchial-pulmonary infection. 3. Intubated for at least 48 h. 4. Meeting Pulmonary infection control window (PIC window). 5. Self-care for the past year. 6. Obtaining informed consent.

Exclusion criteria

Exclusion criteria: 1. Severe organ dysfunction. 2. Patients with chronic neuromuscular disease. 3. Tracheotomy. 4. Upper airway obstruction 5. Facial injury or or oral, esophageal and gastric surgery within one month 6. Patients with NPPV at home 7. Weak cough ability with copious secretions 8. Terminal tumor. 9. Patients with do-not-reintubate order.

Design outcomes

Primary

Measure	Time frame
reintubation rate;	—

Secondary

Measure	Time frame
weaning failure rate;HFNC failure rate;NPPV failure rate;hospital mortality rate;comfort score;adverse reaction;	—

Countries

China

Contacts

Public ContactXie Lixin

Chinese PLA General Hospital

xielx301@126.com+86 13911252807

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026