gingivitis
Conditions
Interventions
Case series:toothpaste
Sponsors
School and Hospital of Stomatology, Wuhan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Agree to sign the informed consent; 2. Aged between 18 and 65 at the time of enrollment; 3. Agree not to participate in any other oral/dental product study during the clinical trial; 4. Agree to postpone general oral treatment or preventive measures (such as tooth cleaning); 5. Agree to suspend the use of any non-research oral care products (including dental floss and mouthwash, etc.) during the study; 6. Agree to come back to participate in the arranged follow-up and follow the study procedures; 7. Without systemic disease; 8. There was no inclination, abnormal development, periodontal pocket, gingival recession, orthodontic appliance wearing and fillings or caries of the tested teeth and adjacent teeth; 9. At least 18 natural teeth with labial/buccal and palatal surfaces.
Exclusion criteria
Exclusion criteria: 1. Using antibiotics, anti-inflammatory or anticoagulant therapy within two weeks prior to baseline examination; 2. Currently participating in any other clinical trials; 3. Pregnant or lactating; 4. Having severe dental caries, extensive filling, crown or periodontal disease; 5. Wearing orthodontic appliance or removable partial denture; 6. Having soft or hard tissue tumors; 7. History of hepatitis, diabetes or other infections; 8. Rheumatic fever, heart murmur, mitral valve prolapse, or other conditions requiring prophylactic antibiotics prior to invasive ophthalmic procedures; 9. History of serious adverse reactions after use of oral care products, such as toothpaste; 10. Oral pain that may interfere with compliance and/or examine or require treatment; 11. Pathological changes of oral mucosa and gums; 12. Smoking or drinking habits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colocalization Rate;The fluorescence intensity ratio of BODIPY/ syto-9; | — |
Countries
China
Contacts
Public ContactWeili Dong
School and Hospital of Stomatology, Wuhan University
Outcome results
None listed