Osteoarthritis
Conditions
Interventions
Group 1:Intraarticular stem cells injection with shame low intensity pulsed ultrasound
Group 2:receive Intraarticular stem cells injection with low intensity pulsed ultrasound
Group 3:Normal saline with low intensity pulsed ultrasound
Sponsors
Tongji Hospital, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Males or females aged 18 Years to 70 Years old; 2. Radiological diagnosis of osteoarthritis using the American College of Rheumatology criteria; 3. Radiological grading of Grade II–III osteoarthritis (OA) of the knee as determined by a qualified radiologist using the Kellgren and Lawrence system; 4. Medial or lateral compartment OA as determined above; 5. Less than 5 degrees varus or valgus knee deformity as measured by the long mechanical axis of the knee on x-ray; 6. A minimum pain score of equal or greater than 5/10 on a visual analogue scale (VAS).
Exclusion criteria
Exclusion criteria: 1. Previous meniscectomy/significant partial meniscectomy or other knee related surgery within the last 12 months; 2. Previous intra-articular injectable therapies within the last 6 months: (1) The patients who have meniscus injury of knee joint need the surgical repair; (2) The patients who have the severe coagulation disorders, cardiopulmonary failure and so on; (3) The women who are pregnant or nursing; (4) There are electronic implants such as pacemakers in the body; (5) The patients who are infected the HIV, the virus of hepatitis or syphilis or Bleeding disorders; (6) The patients with severe cognitive impairment who cannot follow instructions to complete the treatment; (7) History of cancer; (8) Immunodeficiency patients; (9) History of systemic illness or significant organ impairment/failure (i.e., renal failure); (10) The patients who have congenital or acquired knee malformation; (11) Patients or researchers who are participating in other clinical trials believe that other reasons are not appropriate for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Osteoarthritis function assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessment;Global posture analysis;Range of knee motion;cartilage thikness; | — |
Countries
China
Contacts
Public ContactProf .Chen hong
Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed