Malaria
Conditions
Sponsors
Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
0.5 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: 6 months to 60 years old; 2. Uncomplicated falciparum malaria in microscopic examination; 3. The number of asexual protozoa is 2000–200 000/µL in high malaria endemic areas,and is 1000–100 000/µL in low malaria endemic areas; 4. Axillary temperature>= 37.5 degree C or had fevered in 24 hours 5. Having ability to swallow oral medication; 6. Having ability and willingness to abide by the protocol during the study and following the study follow-up; 7. If the patient is a child, should obtain informed consent form from the parent or guardian.
Exclusion criteria
Exclusion criteria: 1. According to the definition of WHO(2000), children under 5 years old with general signs of danger or symptoms of severe falciparum malaria; 2. Mixed malaria patients in microscopic examination; 3. According to the WHO (2006) Child Growth Standard, severely malnourished children; 4. Fever caused by measles, acute lower respiratory tract infection, severe diarrhea with dehydration, other known chronic or serious diseases (such as heart, kidney or liver disease, AIDS) expect malaria 5. Other routine medications that interfere with pharmacokinetics of antimalarial drug 6. Allergic reactions or contraindications to any drug being tested or used as an alternative treatment of the disease; 7. Pregnancy test positive or lactating women; 8. Women of childbearing age who are unable or unwilling to take contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasmodium Density;leukocyte;Hemoglobin;Hematocrit;Blood chemistry;Electrocardiogram;Urine examination;Pregnancy test;Susceptibility test of Plasmodium falciparum in vitro;Molecular marker detection for antimalarial drug resistance;Blood concentration; | — |
Countries
The Republic of Togo
Contacts
Public ContactSong Jianping
Guangzhou University of Chinese Medicine
Outcome results
None listed