A Prospective, Non-interventional, Multi-center Genome-Wide Association Study for HBV Associated Acute-On-Chronic Liver Failure

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900025822

Enrollment

Unknown

Registered

2019-09-09

Start date

2019-09-20

Completion date

Unknown

Last updated

2019-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute-on-chronic liver failure

Interventions

ACLF:non-intervention

CHB:non-intervention

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18-70 years old. HBsAg positive or had a history of chronic hepatitis B or cirrhosis for more than half a year. Gastroenterological symptoms, including fatigue, poor peptide, abdominal distention. Ascites or hepatic encephalopathy. Total bilirubin: > 85umol/L(5mg/dl), PTA 3lgIU/ml (Reference: Guideline for liver failure,Version 2018). 2. Chronic hepatitis B: Age:18-70 years old. HBsAg positive or had a history of chronic hepatitis B or cirrhosis for more than half a year. ALT > 2 ULN, HBV DNA > 3l g IU/ml.

Exclusion criteria

Exclusion criteria: Coinfection with other hepatitis virus; Liver cancer; Autoimmune liver diseases.

Design outcomes

Primary

Measure	Time frame
the 90-day mortality;	—

Countries

China

Contacts

Public ContactYuan Xue

The Third People's Hospital of Changzhou

xueyuan80908@163.com+86 15295077891

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026