Total knee orthopedics
Conditions
Interventions
DP group:0.5ug/kg dexmedetomidine was administered to peripheral nerves
DS group:0.5ug/kg dexmedetomidine for systemic use
C group:Normal saline control group
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Male
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-80 years; 2. Sign the informed consent; 3. ASA:I~III; 4. Meet the indications of knee replacement surgery; 5. Auxiliary examination for admission has been completed.
Exclusion criteria
Exclusion criteria: 1. Dementia patients; 2. Persons with coagulation disorder; 3. Various reasons could not be combined to complete neuropsychological tests, such as visual impairment, hearing impairment, mental illness, etc.; 4. Femoral nerve block is not acceptable due to infection at the puncture site; 5. Sick sinus syndrome and/or heart rate < 50 beats per minute; 6. Recovery from cerebral hemorrhage or cerebral infarction; 7. Allergy to dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of analgesia: time to first report pain (h); | — |
Secondary
| Measure | Time frame |
|---|---|
| age;sex;time of operation;Tourniquet time;BMI;complication;Anesthetic dosage;Use of analgesic drugs after operation;Postoperative nausea and vomiting;Pain score at rest;Pain score during exercise;Sleep satisfaction;Patient satisfaction with pain relief at 72 h;POD;Circumstances requiring remediation of analgesia;Incidence of intraoperative bradycardia;Incidence of intraoperative hypotension;Time of first get out of bed to exercise(h);Length of hospital stay; | — |
Countries
China
Contacts
Public ContactXu Guanghong
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed