HAP
Conditions
Interventions
Standard dose group:Standard dose of tigecycline
High dose group:High dose tigecycline
Sponsors
The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years male and female; 2. Clearly diagnosed as HAP or VAP, HAP is defined as symptoms that appear after 48 hours or more of admission, or symptoms that appear 7 days or less after discharge (first hospitalization time <=3 days). VAP is defined as pneumonia 48 hours or more after tracheal intubation; 3. Bacterial culture of qualified lower respiratory tract specimens is clearly multi-drug resistant Gram-negative bacilli infection; 4. tigecycline sensitive or intermediate, tigecycline is used according to clinical needs; 5. Weight 45 kg to 90 kg; 6. Subjects volunteered to participate and signed informed consent, and the process of signing the informed consent was in accordance with GCP requirements.
Exclusion criteria
Exclusion criteria: 1. patients with known or suspected P. aeruginosa infection; 2. using glucocorticoids (equivalent to 20 mg of prednisone daily for more than 2 weeks) or immunosuppressants, or immunocompromised individuals such as HIV-positive; 3. The patient has an allergic reaction to tigecycline or tetracycline; 4. the person is dying and cannot complete the course of treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day prognosis; | — |
Countries
China
Contacts
Public ContactYuhong Chen
The Fourth Hospital of Hebei Medical University
Outcome results
None listed