Schizophrenia
Conditions
Interventions
electroacupuncture convulsive therapy Group:"Baihui-Renzhong" electroacupuncture convulsive therapy
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18-50 years; 2) Patients diagnosed with schizophrenia by DSM-5; 3) Positive and negative symptom scale (PANSS) score >= 60 points during screening visits and baseline visits; 4) Patients who have been eligible for a one-month washout period; 5) Signing informed consent.
Exclusion criteria
Exclusion criteria: 1) Have a major physical illness or have a history of craniocerebral trauma; 2) Suffering from other neuropsychiatric diseases; 3) There is alcohol or drug abuse in the first 3 months before screening or drug dependence in the first six months before screening; 4) Patients who are allergic to anesthetic drugs and muscle relaxants; 5) Brain occupying lesions and other lesions that increase intracranial pressure; Recent cerebrovascular accidents; Heart disease with unstable heart function; Retinal detachment; Pheochromocytoma; Severe respiratory, liver and kidney diseases; Severe liver dysfunction with hereditary cholinesterase deficiency; Unstable hemangioma or deformity; Severe fractures; Thrombophlebitis. 6) There is obvious abnormal laboratory test result (AST or ALT >= 2 times the upper limit of normal value; BUN >= 1.5 times the upper limit of normal value; Cr >= 1.2 times the upper limit of normal value); QTc interval prolongation (electrocardiogram scan male QTc >= 450 milliseconds, or female QTc >= 470 milliseconds). 7) Can not take medication according to doctor's advice, or no guardian. 8) Pregnant or lactating women, or pregnant women. 9) There are contraindications for magnetic resonance imaging (MRI) can not be performed in some special populations, such as pregnancy, patients with cardiac pacemakers, patients with aneurysm clips after craniocerebral surgery, patients with ferromagnetic implants, patients with artificial metal valves after cardiac surgery, patients with alloy prostheses or metal joints, patients with insulin pumps or nerve stimulators, etc.) 10) Participated in other clinical trials within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG;MRI;PANSS;MCCB; | — |
Secondary
| Measure | Time frame |
|---|---|
| PSP;CDSS; | — |
Countries
China
Contacts
Public ContactYong Xu
The First Hospital of Shanxi Medical University
Outcome results
None listed