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Clinical study for the application of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department: a randomized controlled trial

Clinical study for the application of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department: a randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900025719
Enrollment
Unknown
Registered
2019-09-06
Start date
2019-10-01
Completion date
Unknown
Last updated
2021-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

National natural youth supporting fund and self-raised

Interventions

Control group:The nasal catheter receives oxygen

Sponsors

The First Affiliated Hospital of Zhengzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Aged >= 18 years old, acute dyspnea with hypoxemia and dyspnea (without oxygen, respiratory frequency =24 times/min, pulse oximetry <= 94%); (2) no obvious oropharyngeal active bleeding, no obvious obstruction of sputum discharge; (3) consciousness; (4) the subjects voluntarily participate in the study and have signed the informed consent;

Exclusion criteria

Exclusion criteria: (1) The presence of invasive ventilation indications, must be intubated as soon as possible and invasive ventilator assisted breathing standards; (2) Patients with hemodynamic instability after active fluid resuscitation and vasoactive drugs (systolic blood pressure <90 mmHg, mean arterial pressure <50 mmHg); (3) The Glasgow coma scale is below 13; (4) Refuse to cooperate with active treatment or refuse to participate in this study; (5) Unable to remove respiratory secretions; (6) Malignant tumor history and significantly affect the prognosis; (7) Severe ventricular arrhythmias or myocardial ischemia; (8) There is active bleeding in oropharynx, head, face, airway and chest and abdomen, which has not yet been corrected.

Design outcomes

Primary

MeasureTime frame
respiratory rate;arterial partial pressure of oxygen;

Secondary

MeasureTime frame
hospital stays;Rate of endotracheal intubation during hospitalization;

Countries

China

Contacts

Public ContactLIU QI

The First Affiliated Hospital of Zhengzhou University

Qi.Liu@vip.163.com+86 15981898607

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026