Chronic Bronchitis
Conditions
Interventions
The placebo group:Patients were given a simulated placebo, 4 pills /t.i.d.
treatment group:Patients were given corbrin capsules, 4 capsules /t.i.d.
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. meet the diagnostic criteria for chronic bronchitis; 2. main symptoms of chronic bronchitis (cough, sputum, wheezing) score <= 1; 3. at least 2 acute exacerbations of chronic bronchitis occurred in the past 1 year (confirmed by the treatment records); 4. aged 18-75 (including 18 and 75) years, regardless of gender; 5. volunteer to participate in this clinical trial, give informed consent and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. acute exacerbations of chronic bronchitis occurred in the past 1 month; 2. complicated with tuberculosis, eosinophilic bronchitis, bronchial lung cancer, idiopathic pulmonary fibrosis, bronchial asthma, wheezing, bronchiectasis, cardiac insufficiency, chronic pharyngitis, postnasal drip syndrome or gastroesophageal reflux; 3. the percentage of pulmonary function FEV1 in patients with bronchial dilator inhalation is 1.5 times; 7. long-term history of alcoholism and drug abuse; 8. pregnant and lactating women and women during the trial cannot strictly control contraception; 9. allergic to the ingredients of the tested drugs; 10. participated in other clinical trials in the past 3 months; 11. the researchers considered it inappropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulmonary function (FEV1, FVC, MMEF, PEF);Chest computed tomography;The immune function(Total CD3+T cells, CD3+CD4+T cell subsets, CD3+CD8+T cell subsets CD4+/CD8+T cell subsets);Liver function (ALT, AST, ALP, Tbil, GGT);Renal function (Urea, Scr); | — |
Countries
China
Contacts
Public ContactZhang Hongchun
China-Japan Friendship Hospital
Outcome results
None listed