GvHD
Conditions
Interventions
1:Intermittent infusion of mesenchymal stem cells
Sponsors
General Hospital of PLA
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. 0-14 years old with allogeneic hematopoietic stem cell transplantation; 2. Patients diagnosed as calcineurin intolerance or low dose tolerance (cyclosporine Valley concentration < 50ng/ml, tacrolimus Valley concentration < 5.0ng/ml).
Exclusion criteria
Exclusion criteria: 1. Patients with aGVHD above III or chronic extensive GVHD before admission. 2. In the presence of patients with severe organ failure, the researchers do not think it is suitable for this experiment. 3. Patients with recurrence or relapse tendency of malignant diseases. 4. Severe infection exists, which is not suitable for the experiment. 5. Patients who refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GVHD;Organ toxicity; | — |
Secondary
| Measure | Time frame |
|---|---|
| T B lymphocyte subsets;Dosage of glucocorticoid;Rehabilitation of damaged organs in original CNI;Disease status of malignant diseases; | — |
Countries
China
Contacts
Public ContactRongmu Luo
Outcome results
None listed