periprosthetic joint infection
Conditions
Interventions
Gold Standard:Modified MSIS Criteria
Index test:The results of mNGS
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients with any suspicion of infection after totaljoint arthroplasty (including spacer), such as acute onset of pain or persistent pain since surgery; an increased erythrocyte sedimentation rate (ESR) and/or C-reactiveprotein (CRP) level; or implant failure within 5 years after primary arthroplasty without any reasonable explanation. 2) Patients who are to undergo DAIR or revision arthropalsty.
Exclusion criteria
Exclusion criteria: 1) Patients with other implants, such as a plate or screw in the joint rather than a prothesis; 2) Patients with severe diseases or other risk factors are not suitable for aspiration or hip/knee debridement /revision; 3) Failed aspiration (failed to aspirate any useful fluid, even with saline solution lavage); 3) Patients who were lost to follow-up after aspiration and had insufficient information to determine whether infection was present; 5) Refuse to participate this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| results of culture;results of mNGS;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| sinus tract;ESR;CRP;synovial WBC count;PMN%;LE strip test;frozen section; | — |
Countries
China
Contacts
Public ContactWei Chai
Chinese PLA General Hospital
Outcome results
None listed